The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2008
Filed:
Sep. 27, 2005
Applicants:
Mark Samuel Briggs, Cardiff, GB;
John Anthony Smith, Cardiff, GB;
Albert Francis Santos, Cardiff, GB;
Inventors:
Mark Samuel Briggs, Cardiff, GB;
John Anthony Smith, Cardiff, GB;
Albert Francis Santos, Cardiff, GB;
Assignee:
GE Healthcare UK Limited, Amersham, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); G01N 33/53 (2006.01); C07G 3/00 (2006.01); C07H 19/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides fluorescent cyanine dye-based nucleotide analogues, in which the cyanine dye is coupled to the γ-phosphate group of a nucleoside triphosphate. Preferred embodiments of the invention are directed to fluorescent cyanine dye-based GTP analogues which may be employed in an homogeneous FRET-based assay to measure the binding of guanine nucleotides to GPCR polypeptides, or alternatively, to measure the effect of an exogenous ligand on GPCR protein binding.