Process for the preparation of furopyrroles

Abstract

The present invention relates to a process for the preparation of furopyrroles of general formula (I), comprising (a) heating a compound of the formula (II) under microwave irradiation optionally in the presence of an inert solvent, wherein Aand Aare C-Calkyl, C-Calkenyl, C-Calkynyl, C-Ccycloalkyl, CCcycloalkenyl, aryl or heteroaryl, Ais hydrogen, C-Calkyl, cyanomethyl, Ar, —CRR—(CH)—Aror Y—R, wherein Rand Rindependently of each other stand for hydrogen or C-Calkyl, or phenyl which can be substitute up to three times with C-Calkyl, Arstands for aryl, C-Ccloalkyl, C-Ccycloalkenyl or heteroaryl, which can be substituted one to three times with C-Calkyl, C-Calkoxy, halogen or phenyl, which can be substituted with C-Calkyl or C-Calkoxy one to three times, and m stands for 0, 1, 2, 3 or 4, R is C-Calkyl, in particular C-Calkyl, aryl, in particular phenyl, or aralkyl, in particular benzyl, which can be substituted one to three times with C-Calkyl, C-Calkoxy, or halogen, Y is —C(O)—, —C(O)O—, —C(O)NH—, —SONH— or —SO— and Ris C-Calkyl, Ar, or aralkyl. The furopyrroles of the general formula (I) can be can be obtained in high yield and high purity by the process of the present invention.