The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2008
Filed:
May. 11, 2004
Everett C. Pesci, Greenville, NC (US);
Barbara H. Iglewski, Fairport, NY (US);
Jared B. J. Milbank, Ann Arbor, MI (US);
James P. Pearson, Cambridge, MA (US);
Andrew S. Kende, Pittsford, NY (US);
Everett P. Greenberg, Iowa City, IA (US);
Everett C. Pesci, Greenville, NC (US);
Barbara H. Iglewski, Fairport, NY (US);
Jared B. J. Milbank, Ann Arbor, MI (US);
James P. Pearson, Cambridge, MA (US);
Andrew S. Kende, Pittsford, NY (US);
Everett P. Greenberg, Iowa City, IA (US);
The University of Iowa Research Foundation, Iowa City, IA (US);
University of Rochester, Rochester, NY (US);
East Carolina University, Greenville, NC (US);
Abstract
Novel bacterial quinolone signal molecules and, more particularly,quinolone signal ('PQS') molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.