The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2008
Filed:
Dec. 18, 2006
Juan J. Perez-villar, Santa Monica, CA (US);
Han Chang, Princeton Junction, NJ (US);
Wen-pin Yang, Princeton, NJ (US);
Yuli Wu, Newtown, PA (US);
Gena S. Whitney, Lawrenceville, NJ (US);
Steven B. Kanner, Santa Monica, CA (US);
Juan J. Perez-Villar, Santa Monica, CA (US);
Han Chang, Princeton Junction, NJ (US);
Wen-Pin Yang, Princeton, NJ (US);
Yuli Wu, Newtown, PA (US);
Gena S. Whitney, Lawrenceville, NJ (US);
Steven B. Kanner, Santa Monica, CA (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.