The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 28, 2008

Filed:

Jun. 03, 2004
Applicants:

Huda Y. Zoghbi, Houston, TX (US);

Hugo Bellen, Houston, TX (US);

Nessan Bermingham, Houston, TX (US);

Bassem Hassan, Houston, TX (US);

Nissim Ben-arie, Jerusalem, IL;

Inventors:

Huda Y. Zoghbi, Houston, TX (US);

Hugo Bellen, Houston, TX (US);

Nessan Bermingham, Houston, TX (US);

Bassem Hassan, Houston, TX (US);

Nissim Ben-arie, Jerusalem, IL;

Assignee:

Baylor College of Medicine, Houston, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); C07H 21/02 (2006.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compositions and methods are disclosed for the therapeutic use of an atonal-associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an atonal-associated gene inactivation is also disclosed having at least one atonal-associated nucleic acid sequence replaced by insertion of a heterologous nucleic acid sequence used to detect expression driven by an atonal-associated promoter sequence, wherein the inactivation of the atonal-associated nucleic acid sequence prevents expression of the atonal-associated gene.


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