The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2008
Filed:
Jun. 16, 2003
Applicants:
Biao Jiang, Shanghai, CN;
Yugui SI, Shanghai, CN;
Inventors:
Biao Jiang, Shanghai, CN;
Yugui Si, Shanghai, CN;
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 33/042 (2006.01); C07C 29/42 (2006.01); C07C 215/36 (2006.01); C07D 239/80 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention disclosed a new process of asymmetric alkynylation of ketone or ketimine, involving the chiral ligand-mediated asymmetric addition of zinc or copper acetylide to a trifluoromethyl ketone or ketimine intermediate to give a chiral tertiary proparglic alcohols or amines. The adduct compounds include the key precursors to the potent HIV reverse transcriptase inhibitor Efavirenz (DMP 266), DPC 961 and DPC 083. The invention also disclosed a novel chiral amino alcohol ligand.