The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2008
Filed:
Sep. 07, 2005
Judith Aronhime, Rehovot, IL;
Stefano Bianchi, Como, IT;
Eugenio Castelli, Arlate di Calco, IT;
Paola Daverio, Villasanta, IT;
Silvia Mantovani, Cesano Maderno, IT;
Adrienne Kovacsne-mezei, Debrecen, HU;
Judith Aronhime, Rehovot, IL;
Stefano Bianchi, Como, IT;
Eugenio Castelli, Arlate di Calco, IT;
Paola Daverio, Villasanta, IT;
Silvia Mantovani, Cesano Maderno, IT;
Adrienne Kovacsne-Mezei, Debrecen, HU;
Teva Pharmaceutical Fine Chemicals, Bulciago, IT;
Abstract
The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HCl by adding HCl to a mixture of (R)-(−)-tomoxetine (S)-(+)-mandelate with an organic solvent, with or without a base and water. In preferred embodiments, the atomoxetine hydrochloride produced is Form A.