The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2008
Filed:
Nov. 17, 2004
Applicants:
George R. Pettit, Paradise Valley, AZ (US);
Jun-ping Xu, Chandler, AZ (US);
Inventors:
George R. Pettit, Paradise Valley, AZ (US);
Jun-Ping Xu, Chandler, AZ (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/35 (2006.01); C07D 311/76 (2006.01);
U.S. Cl.
CPC ...
Abstract
The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 0.001 to <0.0001 μg/ml) murine and human cancer cell growth inhibitors, denominated herein as irciniastatin A and irciniastatin B. Both were isolated (10-3 to 10-4% yields) by cancer cell line bioassay-guided techniques and named irciniastatins A (1) and B (2). Structural elucidation by a combination of spectral analyses, primarily high resolution mass and 2D-NMR (principally APT, HMQC, HMBC and ROESY) revealed unusual structures 1 and 2.