The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2008
Filed:
Jul. 14, 2004
Applicants:
Randal J. Kaufman, Ann Arbor, MI (US);
Witoon Tirasphon, Ann Arbor, MI (US);
Ajith A. Welihinda, Ann Arbor, MI (US);
Inventors:
Randal J. Kaufman, Ann Arbor, MI (US);
Witoon Tirasphon, Ann Arbor, MI (US);
Ajith A. Welihinda, Ann Arbor, MI (US);
Assignee:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 15/79 (2006.01); C12N 15/63 (2006.01); C12N 15/52 (2006.01); C12N 1/21 (2006.01);
U.S. Cl.
CPC ...
Abstract
A novel polynucleotide encoding a mammalian bifunctional protein kinase\endoribonuclease referred to herein as hIre1p, is provided. hIre1p is expressed in the endoplasmic reticulum (ER) and upregulates the transcription of genes encoding ER protein chaperones, such as, but not limited to, glucose-related proteins (GRP's). Therapeutic, diagnostic and research methods employing the polynucleotide and protein are also provided.