The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2008
Filed:
Jul. 24, 2006
Philippe Sansonetti, Paris, FR;
Annick Fontaine, Paris, FR;
Philippe Sansonetti, Paris, FR;
Annick Fontaine, Paris, FR;
Institut Pasteur, Paris, FR;
Institut National de la Sante et de la Recherche Medicale, Paris, FR;
Abstract
A method for modifying a wild strain of an entero-invasiveto produce a modified strain ofthat can be used for making a vaccine against the wild strain of. The genome of the wild strain ofis transformed so that it cannot substantially invade cells of a human host and cannot spread substantially within infected cells and from infected to uninfected cells of the host and cannot produce toxins which will kill substantial numbers of the host's infected, as well as uninfected, cells. A first gene of the wild strain of, coding for a protein necessary for theto invade cells of the host, and a second gene, coding for a protein necessary for theto spread within infected cells and between the infected and uninfected cells of the host, are mutagenized.