The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2008
Filed:
Jun. 21, 2002
Eva Gulyas, Debrecen, HU;
Gabor Balogh, Debrecen, HU;
Janos Erdei, Debrecen, HU;
Peter Seress, Debrecen, HU;
Eva Gulyas, Debrecen, HU;
Gabor Balogh, Debrecen, HU;
Janos Erdei, Debrecen, HU;
Peter Seress, Debrecen, HU;
TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság, Debrecen, HU;
Abstract
An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing asp. strain in a submerged medium at a temperature within about 20-30° C. The pH of the fermentation medium is regulated to be at about 5.5-6.0 by feeding the fermentation medium with an assimilable carbon source, a mineral salt, or an acidic/alkali solution. Accordingly, the resulting fermentation broth contains an increased yield of highly purified pseudomonic acid A as the main component. The pseudomonic acid B as an impurity in the fermentation broth is significantly decreased.