The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2008
Filed:
Apr. 30, 1999
Joseph L. Kim, Natick, MA (US);
Kurt Morgenstern, Derry, NH (US);
Paul Caron, Malden, MA (US);
Chao Lin, Brookline, MA (US);
Joseph L. Kim, Natick, MA (US);
Kurt Morgenstern, Derry, NH (US);
Paul Caron, Malden, MA (US);
Chao Lin, Brookline, MA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an oligonucleotide, to crystallizable compositions of HCV helicase and an oligonucleotide and to methods of crystallizing an HCV helicase-oligonucleotide complex. The invention further relates to a computer programmed with the structure coordinates of the HCV helicase oligonucleotide binding pocket or the HCV helicase nucleotide triphosphate pocket wherein said computer is capable of displaying a three-dimensional representation of that binding pocket.