The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2008
Filed:
Apr. 30, 2003
Kenya Shitara, Fujisawa, JP;
Kazuyasu Nakamura, Machida, JP;
Akiko Furuya, Machida, JP;
Rinpei Niwa, Machida, JP;
Yuji Ohki, Machida, JP;
Nobuo Hanai, Princeton, NJ (US);
Kenya Shitara, Fujisawa, JP;
Kazuyasu Nakamura, Machida, JP;
Akiko Furuya, Machida, JP;
Rinpei Niwa, Machida, JP;
Yuji Ohki, Machida, JP;
Nobuo Hanai, Princeton, NJ (US);
Kyowa Hakko Kogyo Co., Ltd., Tokyo, JP;
Abstract
For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides antibodies which have the ability to specifically bind to human IGF-I and IGF-II to thereby inhibit the functions of human IGF-I and IGF-II and have binding activity with a binding constant of 5×10Mor more measured with a biosensor BIACORE. In addition, the present invention provides diagnostics, preventives and remedies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally promoted hIGF production, which use said antibodies.