The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2008
Filed:
Dec. 10, 2004
Andreas Pfaltz, Binningen, CH;
Matthias Lotz, Basel, CH;
Marc Schönleber, Rochestown, IE;
Benoît Pugin, Münchenstein, CH;
Martin Kesselgruber, Basel, CH;
Marc Thommen, Nuglar, CH;
Andreas Pfaltz, Binningen, CH;
Matthias Lotz, Basel, CH;
Marc Schönleber, Rochestown, IE;
Benoît Pugin, Münchenstein, CH;
Martin Kesselgruber, Basel, CH;
Marc Thommen, Nuglar, CH;
Solvias AG, Basel, CH;
Abstract
The invention relates to compounds having a structural element of formula (I) in an aromatic hydrocarbon ring, wherein: M represents —Li, —MgX, (C-C-Alkyl)Sn—, —ZnXor —B(O—C-C-Alkyl); Xand X, independent of one another, represent O or N, and C-bound hydrocarbon radicals or heterohydrocarbon radicals are bound to the free bonds of the O and N atoms; group —C═C—, together with C atoms, forms a hydrocarbon aromatic compound and represents XCl, Br or I. The inventive compounds are easily obtained by directly substituting the hydrogen in the ortho position to the P atom with metalation reagents. The metal atoms can then be substituted by a reactive electrophilic compound. The group —P(X—)(X—) - - - -(BH)can then be converted into a secondary phosphine group. The inventive method enables the production of monophosphines and diphosphines even on a large scale, which are valuable ligands for metal complexes serving as catalysts for, e.g. enantioselective hydrogenations.