The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2008
Filed:
Nov. 28, 2003
José Agustin Quincoces Suárez, São Paulo, BR;
Klaus Peseke, Elmenhors Lichtenhagen, DE;
Markus Kordian, Rostock, DE;
João Ernesto Carvalho, Campinas, BR;
Luciana Konecny Kohn, Campinas, BR;
Márcia Aparecida Antônio, Paulinia, BR;
Heloiza Brunhari, Guarulhos, BR;
José Agustin Quincoces Suárez, São Paulo, BR;
Klaus Peseke, Elmenhors Lichtenhagen, DE;
Markus Kordian, Rostock, DE;
João Ernesto Carvalho, Campinas, BR;
Luciana Konecny Kohn, Campinas, BR;
Márcia Aparecida Antônio, Paulinia, BR;
Heloiza Brunhari, Guarulhos, BR;
Fundação de Amparo a Pesquisa Do Estado de São Paulo, São Paulo, BR;
Abstract
This patent of invention reports the method for the preparation of 1,5-bis(4-hydroxy-3-methoxyphenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties: the sample denominated 37 compound was obtained with high yield and purity with ultrasonic technique presenting cytostatic activity (growth inhibition) in the concentrations evaluated and cytotoxic activity (cellular death) from the concentration of 0.25 mg/mL against nine different types of human cancer cell lines. This compound has a LD, equals to 8.54 g/Kg. That means this product can be considered itself as practically nontoxic. Doxorubicin, anticarcinogen medicine used as reference in all these tests, is a product extremely toxic (LDof 20 mg/Kg) and it does not inhibit the growth of Mama NCI-ADR cell line (the one that expresses the phenotype of resistance against multiple drugs), therefore, out product presented a strong cytostatic activity. Other derivatives also presented a strong cytostatic activity, especially the one denominated EHB1 compound.