The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2008
Filed:
Aug. 12, 2002
Benjamin M. Gaston, Charlottesville, VA (US);
David Gozal, Louisville, KY (US);
Benjamin M. Gaston, Charlottesville, VA (US);
David Gozal, Louisville, KY (US);
University of Virginia Patent Foundation, Charlottesville, VA (US);
University of Louisville Research Foundation, Louisville, KY (US);
Abstract
The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnormalities. Specifically the invention is directed to treating disordered control of breathing by administering an S-nitrosylating agent selected from the group consisting of ethyl nitrite, glutathione, nitric oxide, S-nitrosocysteine, S-nitrosoglutathione, S-nitro-N-acetyl cysteine. As shown in FIG.C the ability of endogenous SNOto increase Vin freely behaving, conscious rates using whole-body plethysmography revealed that CSNO, GSNO and CGSNO (1 nmol each) caused equivalent increases in V, whereas D-CSNO had no effect (left bar graph is the equivalent increases in V, whereas D-CSNO had no effect (left bar graph is the control whereas the right bar represents administration of the respective SNO).