The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2008
Filed:
Sep. 28, 2000
Stephen Arkinstall, Belmont, MA (US);
Serge Halazy, Vetraz-Monthoux, FR;
Dennis Church, Commugny, CH;
Montserrat Camps, Versoix, CH;
Thomas Rueckle, Plan-les-Ouates, CH;
Jean-pierre Gotteland, Beaumont, FR;
Marco Biamonte, San Diego, CA (US);
Stephen Arkinstall, Belmont, MA (US);
Serge Halazy, Vetraz-Monthoux, FR;
Dennis Church, Commugny, CH;
Montserrat Camps, Versoix, CH;
Thomas Rueckle, Plan-les-Ouates, CH;
Jean-Pierre Gotteland, Beaumont, FR;
Marco Biamonte, San Diego, CA (US);
Laboratories Serono SA, Vaud, CH;
Abstract
The present invention is related to sulfonyl hydrazide derivatives for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl hydrazide derivatives. Said sulfonyl hydrazide derivatives are efficient modulators of the JNK pathway, they are in particular efficient inhibitors of JNK 2 and 3. The present invention is furthermore related to novel sulfonyl hydrazide derivatives as well as to methods of their preparation. In Formula (I) Arand Arare independently from each other an unsubstituted or substituted aryl or beteroaryl group, Xand Xare independently from each other O or S; R, R, Rare independently from each other hydrogen or a C-C-alkyl substituent or Rforms a substituted or unsubstituted 5-6-membered saturated or unsaturated ring with Ar; or Rand Rform a substituted or unsubstituted 5-6-membered saturated or unsaturated ring; n is an integer from 0 to 5; G is selected from a group comprising or consisting of an unsubstituted or substituted 4-8 membered heterocycle containing at least one heteroatom, or G is a substituted or unstibstituted C-C-alkyl group.