The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2008
Filed:
Jun. 28, 2005
Mark E. Salvati, Lawrenceville, NJ (US);
James Aaron Balog, Lambertville, NJ (US);
Weifang Shan, Princeton, NJ (US);
Sören Giese, New Hope, PA (US);
Lalgudi S. Harikrishnan, Princeton, NJ (US);
Mark E. Salvati, Lawrenceville, NJ (US);
James Aaron Balog, Lambertville, NJ (US);
Weifang Shan, Princeton, NJ (US);
Sören Giese, New Hope, PA (US);
Lalgudi S. Harikrishnan, Princeton, NJ (US);
Bristol-Myers Squibb Comapny, Princeton, NJ (US);
Abstract
Disclosed are compounds having the formula (I): including compounds of formulae (Ia) and (Ib): wherein G is an optionally substituted aryl or heterocyclo, L is an optional linker, M is a bond, O, CRRor NR, and M' is a bond or NR, with the proviso that at least one of M or M′ must be a bond; E is C=Z, CRCR, SO, P═OR, or P═OOR; Zis O, S, NH, or NR; Ais CRor N; Ais CRor N; Y is J-J′-J″ where J is (CRR)n and n=0−3, J′ is a bond or O, S, S═O, SO, NH, NR, C═O, CO═O, NRC═O, CRR, C═CRR, RP═O, OPOOR, OPO, OSO, C═N, NHNH, NHNR, NRNH, N═N, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo or aryl or substituted aryl, and J″ is (CRR)n and n=0−3; and W, Q, R, R, R, R, R, R, R, R, and Rare as defined in the specification and/or claims herein, to methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and to pharmaceutical compositions containing such compounds.