The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2008
Filed:
Oct. 12, 2005
Vern L. Schramm, New Rochelle, NY (US);
Jef D. Boeke, Baltimore, MD (US);
Anthony Sauvé, Bronx, NY (US);
Ivana Celic, Baltimore, MD (US);
Vern L. Schramm, New Rochelle, NY (US);
Jef D. Boeke, Baltimore, MD (US);
Anthony Sauvé, Bronx, NY (US);
Ivana Celic, Baltimore, MD (US);
Albert Einstein College of Medicine of Yeshiva University, Bronx, NY (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
A novel compound, 2'/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated peptides and NAD. Analogs of 2′/3′-O-acetyl-ADP-ribose are also provided. Additionally, methods of preparing 2′/3′-O-acetyl-ADP-ribose, methods of determining whether a test compound is an inhibitor of a Sir2 enzyme, methods of detecting Sir2 activity in a composition, methods of deacetylating an acetylated peptide, and methods of inhibiting the deacetylation of an acetylated peptide are provided. Prodrugs of 2′/3′-O-acetyl-ADP-ribose are also provided.