The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2008
Filed:
Jun. 08, 2001
Angeline Ingrid Bartholomeusz, Victoria, AU;
Stephen Alister Locarnini, Victoria, AU;
Anna Ayres, Victoria, AU;
Margaret Rose Littlejohn, Victoria, AU;
Geoffrey William Mccaughan, New South Wales, AU;
Peter William Angus, Victoria, AU;
Angeline Ingrid Bartholomeusz, Victoria, AU;
Stephen Alister Locarnini, Victoria, AU;
Anna Ayres, Victoria, AU;
Margaret Rose Littlejohn, Victoria, AU;
Geoffrey William McCaughan, New South Wales, AU;
Peter William Angus, Victoria, AU;
Melbourne Health, Parkville, Victoria, AU;
Austin and Repatriation Medical Centre, Heidelberg, Victoria, AU;
Central Sydney Area Health Service, Camperdown, AU;
Abstract
The present invention relates generally to viral variants exhibiting reduced sensitivity to agents and in particular nucleoside analogues. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues. The variants may also comprise corresponding mutations affecting immunological interactivity to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus.