The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2008
Filed:
Nov. 10, 2003
James M. Robl, Brandon, SD (US);
Yoshimi Kuroiwa, Sioux Falls, SD (US);
Kazuma Tomizuka, Takasaki, JP;
Isao Ishida, Isehara, JP;
James M. Robl, Brandon, SD (US);
Yoshimi Kuroiwa, Sioux Falls, SD (US);
Kazuma Tomizuka, Takasaki, JP;
Isao Ishida, Isehara, JP;
Kirin Holdings Kabushiki Kaisha, Tokyo, JP;
Abstract
The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and a safer source of agricultural products.