The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 30, 2008

Filed:

Jan. 20, 2006
Applicants:

Hassan Abdellaoui, Aliso Viejo, CA (US);

Robert Tam, Irvine, CA (US);

Huanming Chen, Irvine, CA (US);

Varaprasad Chamakura, Irvine, CA (US);

Dinesh Barawkar, Foothill Ranch, CA (US);

Andreas Maderna, Los Angeles, CA (US);

Zhi Hong, Irvine, CA (US);

Stanley Lang, Laguna Niguel, CA (US);

Inventors:

Hassan Abdellaoui, Aliso Viejo, CA (US);

Robert Tam, Irvine, CA (US);

Huanming Chen, Irvine, CA (US);

Varaprasad Chamakura, Irvine, CA (US);

Dinesh Barawkar, Foothill Ranch, CA (US);

Andreas Maderna, Los Angeles, CA (US);

Zhi Hong, Irvine, CA (US);

Stanley Lang, Laguna Niguel, CA (US);

Assignee:

Ardea Biosciences, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 275/03 (2006.01); C07D 413/12 (2006.01); C07D 239/36 (2006.01); C07D 217/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamidines. Also included are the tautomeric isothiazol-3(2H)-ones.


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