The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2008
Filed:
May. 11, 2005
Joseph G. Sodroski, Medford, MA (US);
Richard Wyatt, Andover, MA (US);
Xinzhen Yang, Allston, MA (US);
Michael Farzan, Brookline, MA (US);
Peter D. Kwong, Washington, DC (US);
Joseph G. Sodroski, Medford, MA (US);
Richard Wyatt, Andover, MA (US);
Xinzhen Yang, Allston, MA (US);
Michael Farzan, Brookline, MA (US);
Peter D. Kwong, Washington, DC (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain, at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.