The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2008
Filed:
Oct. 28, 2004
Meng Taing, San Mateo, CA (US);
Shaheer H. Khan, Foster City, CA (US);
Steven M. Menchen, Fremont, CA (US);
Barnett B. Rosenblum, San Jose, CA (US);
Meng Taing, San Mateo, CA (US);
Shaheer H. Khan, Foster City, CA (US);
Steven M. Menchen, Fremont, CA (US);
Barnett B. Rosenblum, San Jose, CA (US);
Applera Corporation, Foster City, CA (US);
Abstract
Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.