Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)

Abstract

The invention provides compounds of formula (I): wherein: Rand Rindependently represent various substituents; Rand Rindependently represent H, F, Cl, Br, Calkyl, Calkoxy, OH, CN, or NO; B represents a sulfur atom or a —CH-group; t represents 3 or 4; and A represents an optionally substituted 5- or 6-membered aromatic heterocyclic ring, or an optionally substituted bicyclic heterocyclic ring system in which at least the ring bound to the group B in Formula (I) is aromatic; or a salt thereof. Preferably, A is selected from one of the groups (i), (ii) or (iii): wherein Xand Xare independently N or CR, and Xis NR, O or S; Yand Yare independently N or CR, and Yis NR, O or S; Zis NR, O or S, and Zand Zare independently N or CR; R, R, and Rare as herein defined, and Ris H, a halogen atom, OH, cyano, nitro, Calkyl, Calkoxy, Calkylenedioxy, Calkanoyl, or Calkylsulfonyl, an optionally substituted 3-, 4-, 5- or 6-membered cycloalkyl ring, or a group of the formula (a), (b), (c) or (d) as defined by the formulas (a), (b), (c) or (d). The compounds are modulators of dopamine Dreceptors and have potential in the treatment of psychotic conditions (e.g. schizophrenia) or substance abuse.