The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2008
Filed:
Aug. 05, 2004
Hidde L. Ploegh, Brookline, MA (US);
Harold A. Chapman, Newton, MA (US);
Richard J. Riese, Brookline, MA (US);
Paula R. Bryant, Cambridge, MA (US);
Matthew S. Bogyo, San Francisco, CA (US);
Hidde L. Ploegh, Brookline, MA (US);
Harold A. Chapman, Newton, MA (US);
Richard J. Riese, Brookline, MA (US);
Paula R. Bryant, Cambridge, MA (US);
Matthew S. Bogyo, San Francisco, CA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Brigham and Women's Hospital, Boston, MA (US);
Abstract
Methods and products for suppressing a class II MHC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby reducing the competency of class II MHC molecules for binding antigenic peptides, reducing presentation of antigenic peptides by class II MHC molecules, and suppressing immune responses. The methods may be employed in the treatment of autoimmune diseases, allergic responses, and organ or tissue graft rejection. Pharmaceutical and therapeutic compositions which are peptide based inhibitors of cathepsin S are also described.