The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2008
Filed:
Nov. 01, 2002
Jonathan S. Dordick, Schenectady, NY (US);
Aravind Srinivasan, Cambridge, MA (US);
Jungbae Kim, Seoul, KR;
David H. Sherman, Ann Arbor, MI (US);
Douglas S. Clark, Orinda, CA (US);
Jonathan S. Dordick, Schenectady, NY (US);
Aravind Srinivasan, Cambridge, MA (US);
Jungbae Kim, Seoul, KR;
David H. Sherman, Ann Arbor, MI (US);
Douglas S. Clark, Orinda, CA (US);
Rensselaer Polytechnic Institute, Troy, MI (US);
Darpa, Arlington, VA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a means for sequentially directing a starting material and each ensuing reaction product to the enzymes of the biosynthetic pathway in the order corresponding to the steps of the biosynthetic pathway. The device can thus be used to prepare the natural product using the natural starting material of the biosynthetic pathway or analogs of the natural product using an unnatural starting material. Alternatively, artificial pathways can be created by immobilizing an appropriate selection of enzymes on the device in an order whereby each subsequent enzyme can catalyze a reaction with the product of the prior enzyme. Novel chemical entities can be prepared from these artificial pathways.