The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2008
Filed:
Dec. 27, 2004
Tetsuya Kawahara, Tsukuba, JP;
Makoto Kotake, Tsukuba, JP;
Naoki Yoneda, Tsukuba, JP;
Shinsuke Hirota, Tsukuba, JP;
Masayoshi Ohkuro, Tsukuba, JP;
Tetsuya Kawahara, Tsukuba, JP;
Makoto Kotake, Tsukuba, JP;
Naoki Yoneda, Tsukuba, JP;
Shinsuke Hirota, Tsukuba, JP;
Masayoshi Ohkuro, Tsukuba, JP;
Eisai R&D Management Co., Ltd., Tokyo, JP;
Abstract
In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome; rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.