The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2008
Filed:
Jun. 14, 2002
Applicants:
Bent Karsten Jakobsen, Oxfordshire, GB;
Meir Glick, Stoughton, MA (US);
Inventors:
Bent Karsten Jakobsen, Oxfordshire, GB;
Meir Glick, Stoughton, MA (US);
Assignee:
MediGene Limited, Oxfordshire, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); C07K 14/725 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides modified CD8 molecules whose binding to MHC is enhanced compared to wild-type CD8, wherein Serof at least one CD8α chain thereof is mutated to another amino acid. It also provides nucleic acids encoding such molecules and methods of using such molecules and nucleic acids in immunosuppressive therapy, in particular as inhibitors of cytotoxic T cell responses.