The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2008
Filed:
Mar. 16, 2006
Jonathan F. Smith, Cary, NC (US);
Kurt I. Kamrud, Apex, NC (US);
Jonathan O. Rayner, Apex, NC (US);
Sergey A. Dryga, Chapel Hill, NC (US);
Ian J. Caley, Durham, NC (US);
Jonathan F. Smith, Cary, NC (US);
Kurt I. Kamrud, Apex, NC (US);
Jonathan O. Rayner, Apex, NC (US);
Sergey A. Dryga, Chapel Hill, NC (US);
Ian J. Caley, Durham, NC (US);
AlphaVax, Inc., Research Triangle Park, NC (US);
Abstract
The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication competent alphavirus particles, as determined by passage on cells in culture. The compositions include helper and replicon nucleic acid molecules that can further reduce the predicted frequency for formation of replication-competent virus and can optimize manufacturing strategies and costs.