The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2008
Filed:
Sep. 27, 2006
Michael Sela, Rehovot, IL;
Masha Fridkis-hareli, Cambridge, MA (US);
Jack L. Strominger, Lexington, MA (US);
Rina Aharoni, Rehovot, IL;
Dvora Teitelbaum, Rehovot, IL;
Ruth Arnon, Rehovot, IL;
Michael Sela, Rehovot, IL;
Masha Fridkis-Hareli, Cambridge, MA (US);
Jack L. Strominger, Lexington, MA (US);
Rina Aharoni, Rehovot, IL;
Dvora Teitelbaum, Rehovot, IL;
Ruth Arnon, Rehovot, IL;
Yeda Research and Development Co., Ltd., Rehovot, IL;
President and Fellows of Harvard University, Cambridge, MA (US);
Abstract
The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.