The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2008
Filed:
Apr. 09, 2003
Applicants:
Amanda Proudfoot, Chens sur Leman, FR;
Marie Kosco-vilbois, Minzier, FR;
Tracy Handel, Oakland, CA (US);
Inventors:
Amanda Proudfoot, Chens sur Leman, FR;
Marie Kosco-Vilbois, Minzier, FR;
Tracy Handel, Oakland, CA (US);
Assignee:
Laboratoires Serono SA, Coinsins, Vaud, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01); C12N 5/10 (2006.01); C12N 15/19 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
Abstract
Novel antagonists of MCP proteins, in particular of MCP-1 protein, can be obtained by generating MCP mutants whose GAG binding site, located at the N-terminal of MCP proteins, is eliminated following non-conservative substitutions. Compounds prepared in accordance with the present invention can be used in the treatment or prevention of diseases related to an undesirable activity of MCP proteins such, such as inflammatory disease, autoimmune diseases, vascular diseases, and cancer.