The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2008
Filed:
Feb. 05, 2004
Takeshi Yura, Aichi-ken, JP;
Muneto Mogi, Nara-ken, JP;
Hiroshi Fujishima, Nara-ken, JP;
Klaus Urbahns, Lund, SE;
Tsutomu Masuda, Aichi-ken, JP;
Yasuhiro Tsukimi, Hyogo-ken, JP;
Masaomi Tajimi, Aichi-ken, JP;
Noriyuki Yamamoto, Osaka-fu, JP;
Nagahiro Yoshida, Kyoto-fu, JP;
Toshiya Moriwaki, Nara-ken, JP;
Takeshi Yura, Aichi-ken, JP;
Muneto Mogi, Nara-ken, JP;
Hiroshi Fujishima, Nara-ken, JP;
Klaus Urbahns, Lund, SE;
Tsutomu Masuda, Aichi-ken, JP;
Yasuhiro Tsukimi, Hyogo-ken, JP;
Masaomi Tajimi, Aichi-ken, JP;
Noriyuki Yamamoto, Osaka-fu, JP;
Nagahiro Yoshida, Kyoto-fu, JP;
Toshiya Moriwaki, Nara-ken, JP;
Bayer Healthcare AG, Leverkusen, DE;
Abstract
This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excellent activity as VR1 antagonist and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.