The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2008
Filed:
Nov. 22, 2005
Applicants:
William Brown, St. Laurent, CA;
Niklas Plobeck, Södertälje, SE;
Inventors:
William Brown, St. Laurent, CA;
Niklas Plobeck, Södertälje, SE;
Assignee:
AstraZeneca AB, Sodertalje, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/12 (2006.01); C07D 317/44 (2006.01); C07C 303/00 (2006.01); C07C 307/00 (2006.01); C07C 309/00 (2006.01); C07C 311/00 (2006.01); C07C 233/00 (2006.01); C07C 235/00 (2006.01); C07C 237/00 (2006.01); C07C 239/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
An asymmetric synthesis of diarylmethylpiperazines is described. The synthetic route enables preparation of a variety of enatiomerically pure amines with different N-alkyl groups. The invention includes an asymmetric addition of organometallic compounds to chiral sulfinimine to give adducts in predominantly one diastereomer can subsequently be transferred into pure enantiomers of by cleavage of the chiral auxilliary which is followed by synthesis of the piperazine ring by alkylation procedures.