The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2008
Filed:
Mar. 27, 2003
Michael Philip Cohen, Indianapolis, IN (US);
Daniel Timothy Kohlman, Camby, IN (US);
Sidney Xi Liang, Bethany, CT (US);
Vincent Mancuso, Thy-le-Chateau, BE;
Yao-chang Xu, Fishers, IN (US);
Bai-ping Ying, Fishers, IN (US);
Deanna Piatt Zacherl, Noblesville, IN (US);
Deyi Zhang, Carmel, IN (US);
Frantz Victor, Indianapolis, IN (US);
Michael Philip Cohen, Indianapolis, IN (US);
Daniel Timothy Kohlman, Camby, IN (US);
Sidney Xi Liang, Bethany, CT (US);
Vincent Mancuso, Thy-le-Chateau, BE;
Yao-Chang Xu, Fishers, IN (US);
Bai-Ping Ying, Fishers, IN (US);
DeAnna Piatt Zacherl, Noblesville, IN (US);
Deyi Zhang, Carmel, IN (US);
Frantz Victor, Indianapolis, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; Ris C-Calkyl, substituted C-Calkyl, C-Ccycloalkyl, substituted C-Ccycloalkyl, C-Ccycloalkyl-C-Calkyl, substituted C-Ccycloalkyl-C-Calkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; Ris hydrogen, C-Calkyl, C-Ccycloalkyl-C-Calkyl, or a group of formula II Ris hydrogen or C-Calkyl; Ris hydrogen, halo, or C-Calkyl; Ris hydrogen or C-Calkyl; Ris hydrogen or C-Calkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HTreceptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.