The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2008
Filed:
Jun. 20, 2003
Daniel Christopher Brookings, Reading, GB;
Jeremy Martin Davis, Wokingham, GB;
Barry John Langham, Reading, GB;
Daniel Christopher Brookings, Reading, GB;
Jeremy Martin Davis, Wokingham, GB;
Barry John Langham, Reading, GB;
Celltech R&D Limited, Berkshire, GB;
Abstract
Bicyclic heteroaromatic derivatives of formula (1) are described: F (1) where: the dashed line joining A and C(R) is present and represents a bond and A is a —N═ atom or a —C(R)═ group, or the dashed line is absent and A is a —N(R)—, or —C(R)(R)— group; X is an —O—, —S— or substituted nitrogen atom or a —S(O)—, —S(O)— or —NH-group; Y is a nitrogen or substituted carbon atom or a —CH═ group; n is zero or the integer 1; Alkis an optionally substituted aliphatic or heteroaliphatic chain Lis a covalent bond or a linker atom or group; Cyis a hydrogen atom or an optionally substituted cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; Ar is an optionally substituted aromatic or heteroaromatic group; and the remaining substituents are defined in the specification. The compounds are potent and selective inhibitors of p38 kinase and are of use in the prophylaxis and treatment of immune or inflammatory disorders.