The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2008
Filed:
Jan. 09, 2002
Tapas Mukhopadhyay, Houston, TX (US);
Sunil Chada, Missouri City, TX (US);
Abner Mhashilkar, Houston, TX (US);
Jack A. Roth, Houston, TX (US);
Tapas Mukhopadhyay, Houston, TX (US);
Sunil Chada, Missouri City, TX (US);
Abner Mhashilkar, Houston, TX (US);
Jack A. Roth, Houston, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Introgen Therapeutics, Inc., Austin, TX (US);
Abstract
The present invention is directed to the use of benzimidazole derivatives for the treatment of tumors and in combination with tumor suppressor gene therapy. In a particular embodiment, treatment of p53-positive tumors with benzimidazole derivatives induces p53 expression and increases its half-life, resulting in apoptotic death of the tumor cells. Similarly, in conjunction with p53 gene therapy, benzimidazole derivatives induce p53 expression and accumulation in tumor cells regardless of their p53 status. The combination treatment subsequently elicits apoptosis of the tumor cells.