The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2008
Filed:
Nov. 29, 2001
Ramachandran Ranganathan, Kensington, CA (US);
Kondareddiar Ramalingam, Dayton, NJ (US);
Radhakrishua Pillai, Cranbury, NJ (US);
Edmund E. Marinelli, Lawrenceville, NJ (US);
Rolf E. Swenson, Princeton, NJ (US);
Ramachandran Ranganathan, Kensington, CA (US);
Kondareddiar Ramalingam, Dayton, NJ (US);
Radhakrishua Pillai, Cranbury, NJ (US);
Edmund E. Marinelli, Lawrenceville, NJ (US);
Rolf E. Swenson, Princeton, NJ (US);
Bracco International B.V., Amsterdam, NL;
Abstract
Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLecompositions. In particular, the disclosed SLecompounds can be used to prepare selectin binding ligand conjugates by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLecompounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl Le, and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.