The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2008
Filed:
Dec. 01, 2003
Charles Mioskowski, Strasbourg, FR;
Alain Wagner, Strasbourg, FR;
Sandra DE Lamo Marin, Strasbourg, FR;
Cedric Catala, Strasbourg, FR;
Jean-michel Becht, Brunstatt, FR;
Charles Mioskowski, Strasbourg, FR;
Alain Wagner, Strasbourg, FR;
Sandra De Lamo Marin, Strasbourg, FR;
Cedric Catala, Strasbourg, FR;
Jean-Michel Becht, Brunstatt, FR;
Centre National de la Recherche Scientifique (C.N.R.S.), Paris, FR;
Universite Louis Pasteur, Strasbourg, FR;
Abstract
The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting in the derivatives of formula (I), or in obtaining at least a lactone of structure (III) in racemic form(s), or a enantiomerically enriched mixture, followed by opening, in basic conditions, in an aprotic or protic solvent, the desired lactone(s) and, optionally, separating the desired form. The invention is useful for preparing in particular (2S, 3R, 4S)-4-hydroxyisoleucine.