The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2008
Filed:
Jan. 05, 2005
Emma Bratt, Mölndal, SE;
Yantao Chen, Mölndal, SE;
Kenneth Granberg, Mölndal, SE;
Ingemar Nilsson, Mölndal, SE;
Emma Bratt, Mölndal, SE;
Yantao Chen, Mölndal, SE;
Kenneth Granberg, Mölndal, SE;
Ingemar Nilsson, Mölndal, SE;
AstraZeneca AB, Sodertalje, SE;
Abstract
The invention relates to heterocyclic derivatives of formula (I), wherein Ris amino, a group ORor a group —Y—Rwhere Ris hydrogen or Calkyl, Y is Calkylene, Ris hydrogen, halo, hydroxy, Calkoxy, CalkoxyCalkoxyC, or a group NRRwhere Rand Rare independently selected from hydrogen, Calkyl, hydroxyCalkyl or alkoxyCalkyl, or Rand Rtogether with the nitrogen atom to which they are attached form a saturated 5-6-membered heterocyclic ring which optionally contains an additional heteroatom; n is one or two and each Ris independently selected from halo, haloCalkyl, hydroxy, oxo, amino, Calkylamino or di-Cdialkylamino; or a pharmaceutically acceptable salt thereof. These compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.