The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2008
Filed:
Aug. 05, 2003
J. Milton Harris, Huntsville, AL (US);
Francesco Maria Veronese, Padua, IT;
Paola Caliceti, Padua, IT;
Oddone Schiavon, Padua, IT;
J. Milton Harris, Huntsville, AL (US);
Francesco Maria Veronese, Padua, IT;
Paola Caliceti, Padua, IT;
Oddone Schiavon, Padua, IT;
Nektar Therapeutics AL, Corporation, Huntsville, AL (US);
Abstract
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polyand poly, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGand mPEGhave the structure CHO—(CHCHO)CHCH— wherein n may be the same or different for poly- and poly- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.