The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2008
Filed:
Feb. 03, 2006
Stefano Turchetta, Rome, IT;
Angela Tuozzi, Rome, IT;
Elio Ullucci, Latina, IT;
Lorenzo DE Ferra, Rome, IT;
Stefano Turchetta, Rome, IT;
Angela Tuozzi, Rome, IT;
Elio Ullucci, Latina, IT;
Lorenzo De Ferra, Rome, IT;
Chemi SpA, Milan, IT;
Abstract
The present invention relates to a process for the preparation of Montelukast and the salts thereof comprising the following steps: (a) reaction of a compound A with a compound A in which n varies between 1 and 2 and, when n is 1, R is methyl and, when n is 2, R is a C-Calkyl or an aryl, and X is a leaving group, by nucleophilic substitution reactions in dipolar organic solvents to yield the compound A3 (b) reaction of the compound A3 with an inorganic acid HY, in which Y is Cl, Br, I, and subsequent isolation of the resultant salt A4; (c) optional conversion of the salt A4 into the compound A3;(d) methylation of the salt A4 and/or of the compound A3 to yield Montelukast.