The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2008
Filed:
Aug. 30, 2003
Douglas J Dellinger, Boulder, CO (US);
Agnieszka B. Sierzchala, Boulder, CO (US);
Marvin H Caruthers, Loveland, CO (US);
Geraldine F Dellinger, Boulder, CO (US);
Douglas J Dellinger, Boulder, CO (US);
Agnieszka B. Sierzchala, Boulder, CO (US);
Marvin H Caruthers, Loveland, CO (US);
Geraldine F Dellinger, Boulder, CO (US);
Agilent Technologies, Inc., Santa Clara, CA (US);
Abstract
Methods of forming an internucleotide bond are disclosed. Such methods find use in synthesis of polynucleotides. The method involves contacting a functionalized support with a precursor having an exocyclic amine triaryl methyl protecting group under conditions and for a time sufficient to result in internucleotide bond formation. The functionalized support includes a solid support, a triaryl methyl linker group, and a nucleoside moiety having a reactive site hydroxyl, the nucleoside moiety attached to the solid support via the triaryl methyl linker group. In particular embodiments, the precursor has the structure: wherein: