The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2008
Filed:
Sep. 27, 2001
Serge Halazy, Vetraz-Monthoux, FR;
Dennis Church, Commugny, CH;
Stephen J. Arkinstall, Belmont, MA (US);
Marco Biamonte, San Diego, CA (US);
Montserrat Camps, Versoix, CH;
Jean-pierre Gotteland, Beaumont, FR;
Thomas Rueckle, Plan-les-Ouates, CH;
Serge Halazy, Vetraz-Monthoux, FR;
Dennis Church, Commugny, CH;
Stephen J. Arkinstall, Belmont, MA (US);
Marco Biamonte, San Diego, CA (US);
Montserrat Camps, Versoix, CH;
Jean-Pierre Gotteland, Beaumont, FR;
Thomas Rueckle, Plan-les-Ouates, CH;
Laboratoires Serono S.A., Coinsins, CH;
Abstract
The present invention is related to benzsulfonamide derivatives of formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzsulfonamide derivatives. Said benzsulfonamide derivatives are ef-ficient modulators of the JNK pathway, they are in particular efficient and selective in-hibitors of JNK 2 and 3. The present invention is furthermore related to novel benzsul-fonamide derivatives as well as to methods of their preparation (I). The compounds of formula I according to the present invention being suitable pharma-ceutical agents are those wherein Ar1 is a substituted or unsubstituted aryl or heteroaryl group. X is O or S, preferably O.R1 is hydrogen or a C1-C6-alkyl group, preferably H.R2 is hydrogen, —COOR3, —CONR3R3', OH, a C1-C4 alkyl substituted with an OH group, a hydrazido carbonyl group, a sulfate, a sulfonate, an amine or an ammonium salt; n is either 0 or 1, preferably 1.