The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 26, 2008

Filed:

Feb. 25, 2005
Applicants:

Brian E. Fink, West Windsor, NJ (US);

Ashvinikumar V. Gavai, Princeton Junction, NJ (US);

Gregory D. Vite, Titusville, NJ (US);

Wen-ching Han, Newtown, PA (US);

Raj N. Misra, Hopewell, NJ (US);

Hai-yun Xiao, Belle Mead, NJ (US);

Derek J. Norris, Pennington, NJ (US);

John S. Tokarski, Princeton, NJ (US);

Inventors:

Brian E. Fink, West Windsor, NJ (US);

Ashvinikumar V. Gavai, Princeton Junction, NJ (US);

Gregory D. Vite, Titusville, NJ (US);

Wen-Ching Han, Newtown, PA (US);

Raj N. Misra, Hopewell, NJ (US);

Hai-Yun Xiao, Belle Mead, NJ (US);

Derek J. Norris, Pennington, NJ (US);

John S. Tokarski, Princeton, NJ (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/33 (2006.01); C07D 225/04 (2006.01); C07D 267/22 (2006.01); C07D 281/18 (2006.01); C07D 291/00 (2006.01); C07D 337/16 (2006.01); A01N 43/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are fused tricyclic compounds of the following formula I, or an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof. The disclosed compounds are useful as inhibitors of 17β-hydroxysteriod dehydrogenase 3 (17βHSD3). Also disclosed are methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer and pharmaceutical compositions comprising such compounds.


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