The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2008
Filed:
May. 13, 2002
Kristina Allen, Hopkinton, MA (US);
Anthony Anisowicz, West Newton, MA (US);
James R. Graham, Arlington, MA (US);
Arturo Morales, Arlington, MA (US);
Paul J. Yaworsky, Rockland, MA (US);
Wei Liu, Sudbury, MA (US);
Kristina Allen, Hopkinton, MA (US);
Anthony Anisowicz, West Newton, MA (US);
James R. Graham, Arlington, MA (US);
Arturo Morales, Arlington, MA (US);
Paul J. Yaworsky, Rockland, MA (US);
Wei Liu, Sudbury, MA (US);
Oscient Pharmaceuticals Corporation, Waltham, MA (US);
Wyeth, Madison, NJ (US);
Abstract
The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.