The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2008
Filed:
May. 19, 2003
James M. Robl, Brandon, SD (US);
Poothappillai Kasinathan, Sioux Falls, SD (US);
Richard A. Goldsby, Leverett, MA (US);
Yoshimi Kuroiwa, Sioux Falls, SD (US);
Kazuma Tomizuka, Takasaki, JP;
Isao Ishida, Isehara, JP;
Barbara Osborne, Leverett, MA (US);
James M. Robl, Brandon, SD (US);
Poothappillai Kasinathan, Sioux Falls, SD (US);
Richard A. Goldsby, Leverett, MA (US);
Yoshimi Kuroiwa, Sioux Falls, SD (US);
Kazuma Tomizuka, Takasaki, JP;
Isao Ishida, Isehara, JP;
Barbara Osborne, Leverett, MA (US);
Kirin Beer Kabushiki Kaisha, Tokyo, JP;
Abstract
The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.