The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2008
Filed:
Nov. 21, 2005
Masahiko Isaka, Bangkok, TH;
Nigel Leslie Hywel-jones, Bangkok, TH;
Sayanh Somrithipol, Pathumthani, TH;
Kanyawim Kirtikara, Pathumthani, TH;
Prasit Palittapongarnpim, Bangkok, TH;
Yodhathai Thebtaranonth, Pathumthani, TH;
Masahiko Isaka, Bangkok, TH;
Nigel Leslie Hywel-Jones, Bangkok, TH;
Sayanh Somrithipol, Pathumthani, TH;
Kanyawim Kirtikara, Pathumthani, TH;
Prasit Palittapongarnpim, Bangkok, TH;
Yodhathai Thebtaranonth, Pathumthani, TH;
Abstract
Three new alkaloids, Hirsutellones A, B, and C, are produced in cultures of fungus such asstrain BCC 2594 andsp. strain BCC 7579. The Hirsutellones exhibited potent growth inhibitory activity against(H37Ra strain) with an MIC value of 0.78 μg/ml, while showing weak or no cytotoxicity to mammalian cells. Therefore, Hirsutellones and pharmaceutical compositions containing Hirsutellones may be useful for the treatment of tuberculosis. Also described herein are methods of isolating the Hirsutellones.