4,5-dihydro-isoxazole derivatives and their pharmaceutical use

Abstract

The present invention is concerned with the compounds of formula wherein m, n and p are each independently 0 or 1 and q is 0, 1, 2, 3, 4 or 5; -A=A-A=A- is a pyridinylidene, pyridazinylidene, pyrimidinylidene, pyrazinylidene or phenylidene; B represents an amide, ketone or oxadiazole; D represents Ar or Het; Q represents a covalent direct bond or a ketone, —N—, —O—, —CRR—, amide, ethenyl, imine, sulfonyl, sulfinyl, 3-oxobutenyl, pyrazole, isoxazole or thiazole; L represents Ar or Het; Rrepresents hydrogen, halo, hydroxy, Calkenyl, Calkynyl, Ccycloalkyl, Ccycloalkenyl, cyano, guanidine, nitro, NRR, an optionally substituted Calkyl or Calkyloxy; Rand Reach independently represent hydrogen, halo, Calkyloxy or an optionally substituted Calkyl; Rand Reach independently represent hydrogen, hydroxy, halo, an optionally substituted Calkyl, Calkenyl, Calkynyl, Ccycloalkyl, Ccycloalkenyl, Calkyloxy, cyano, (C═O)R, (C—O)OR, (SO)R, aminocarbonyloxy, aminoCalkyl, NRR, N, Ar or Het; or Rand Rtogether with the carbon atom to which they are attached, form an Ar or Het; Ar represents an optionally substituted Caryl; Het represents an optionally substituted Cheterocycle; or a N-oxide, pharmaceutically acceptable addition salt, quaternary amine or stereochemically isomeric form thereof; the processes for their preparation and compositions comprising them. It further relates to their use as a medicine.