The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2008
Filed:
Sep. 24, 2004
Joseph D. Gold, San Francisco, CA (US);
Melissa K. Carpenter, London, CA;
Margaret S. Inokuma, San Jose, CA (US);
Chunhui Xu, Palo Alto, CA (US);
Joseph D. Gold, San Francisco, CA (US);
Melissa K. Carpenter, London, CA;
Margaret S. Inokuma, San Jose, CA (US);
Chunhui Xu, Palo Alto, CA (US);
Geron Corporation, Menlo Park, CA (US);
Abstract
This disclosure provides a system for obtaining genetically altered primate pluripotent stem (pPS) cells. The role of the feeder cells is replaced by supporting the culture on an extracellular matrix, and culturing the cells in a conditioned medium. The cells can be genetically altered with a viral vector or DNA/lipid complex, and then selected for successful transfection by drug-resistant phenotype in the transfected cells. The system allows for bulk proliferation of genetically altered pPS cells as important products for use in human therapy or drug screening.